Robert Neville is a scientist who was unable to stop the spread of the terrible virus that was incurable and man-made. Immune, Neville is now the last human survivor in what is left of New York City and perhaps the world. For three years, Neville has faithfully sent out daily radio messages, desperate to find any other survivors who might be out there. But he is not alone. Mutant victims of the plague -- The Infected -- lurk in the shadows... watching Neville's every move... waiting for him to make a fatal mistake. Perhaps mankind's last, best hope, Neville is driven by only one remaining mission: to find a way to reverse the effects of the virus using his own immune blood. But he knows he is outnumbered... and quickly running out of time. Written by Warner Bros. Pictures

Lewis, Sheriff and Tony are three friends vacationing in Malaysia. Sheriff and Tony eventually leave to pursue careers in New York, but Lewis stays behind to work with orangutans. Two years later, Sheriff and Tony learn that, because of their past actions, Lewis has been arrested for drug possession. With Lewis facing a death sentence, the friends are left with a difficult decision: return to Malaysia and split Lewis' sentence, or let him die.